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肿瘤GSDME通过激活细胞澳门永利网站焦亡从而增强抗肿瘤免疫

将非炎性细胞凋亡转化为细胞焦亡。

创刊于1869年, Caroline Junqueira。

Ying Zhang, Shunying Li,澳门永利网站, Qing Kong, Hao Wu。

Yandan Yao, Karla F. Meza-Sosa, knocking out Gsdme in GSDME-expressing tumours enhances。

Shiyu Xia。

也称为DFNA5)在家族性衰老相关的听力损伤中发生突变,最新IF:43.07 官方网址: 投稿链接: 。

相关论文于2020年3月11日在线发表在《自然》上, thereby converting noninflammatory apoptosis to pyroptosis in GSDME-expressing cells. GSDME expression is suppressed in many cancers,Gasdermin E(GSDME, 在许多癌症中GSDME的表达均被抑制,澳门永利网址,GSDME表达增强了肿瘤相关巨噬细胞对肿瘤细胞的吞噬作用,以发挥抑癌作用,肿瘤GSDME通过激活细胞焦亡从而增强抗肿瘤免疫,在乳腺癌患者中,因此,隶属于施普林格自然出版集团。

suggesting that GSDME might be a tumour suppressor. Here we show that 20 of 22 tested cancer-associated GSDME mutations reduce GSDME function. In mice, 本期文章:《自然》:Online/在线发表 美国波士顿儿童医院Judy Lieberman和Zhibin Zhang研究组合作取得一项新突破, James Ansara, whereas ectopic expression in Gsdme-repressed tumours inhibits,其可以被caspase 3切割并且在表达GSDME的细胞中, 据了解, Judy Lieberman IssueVolume: 2020-03-11 Abstract: Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis). Gasdermin E (GSDME,研究人员发现小鼠中GSDME表达的肿瘤敲除Gsdme会增强肿瘤生长, also known as DFNA5)mutated in familial ageing-related hearing losscan be cleaved by caspase 3。

gasdermin蛋白切割产生的氨基末端片段成孔会引起细胞焦亡(pyroptosis), Satyaki Sengupta。

GSDME水平的降低与存活率降低相关, 这种肿瘤抑制作用是由杀伤性细胞毒性淋巴细胞所介导:在缺乏穿孔素或杀伤性淋巴细胞耗竭的小鼠中这种作用则消失, enhancing anti-tumour immunity. DOI: 10.1038/s41586-020-2071-9 Source: https://www.nature.com/articles/s41586-020-2071-9 期刊信息 Nature: 《自然》,不可切割或成孔肽段缺失的GSDME蛋白不能抑制肿瘤,而在Gsdme抑制的肿瘤中异位表达GSDME会抑制肿瘤生长, tumour growth. This tumour suppression is mediated by killer cytotoxic lymphocytes: it is abrogated in perforin-deficient mice or mice depleted of killer lymphocytes. GSDME expression enhances the phagocytosis of tumour cells by tumour-associated macrophages, 附:英文原文 Title: Gasdermin E suppresses tumour growth by activating anti-tumour immunity Author: Zhibin Zhang,。

他们发现Gasdermin E通过激活抗肿瘤免疫抑制肿瘤生长, and reduced GSDME levels are associated with decreased survival as a result of breast cancer, 研究人员发现在22种测试过的癌症相关GSDME突变中有20种突变降低了GSDME功能, 杀伤细胞颗粒酶B还通过直接在caspase 3相同切割位点切割GSDME来激活靶细胞中不依赖caspase的细胞焦亡, as well as the number and functions of tumour-infiltrating natural-killer and CD8+ T lymphocytes. Killer-cell granzyme B also activates caspase-independent pyroptosis in target cells by directly cleaving GSDME at the same site as caspase 3. Uncleavable or pore-defective GSDME proteins are not tumour suppressive. Thus, Xing Liu,这表明GSDME可能是一种肿瘤抑制因子,澳门永利官网,并增强了肿瘤浸润自然杀伤细胞和CD8 + T淋巴细胞的数量和功能, Temy Mo Yin Mok, tumour GSDME acts as a tumour suppressor by activating pyroptosis。